Airport Center is situated eight miles north of the San Antonio Central Business District at the southeast corner of Reunion Place and US Highway 281 and within minutes of the San Antonio International Airport.
Take I-35 South, exit 166 to merge onto I-410 W. In 5 miles, take exit 21 toward Airport Blvd/US-281 S. Merge onto NE Interstate 410 Loop Frontage Rd. Turn right onto McAllister Fwy. In less than a mile, turn right onto Reunion Pl.
Head northwest on E Terminal Dr, Turn right onto S Terminal Dr. Take the 2nd right onto McAllister Fwy. In half mile, turn right onto Reunion Pl.
From I-35 South:
Take I-35 North, exit 158 toward TX-368 Loop/Broadway. Follow signs for US-281 N/Mc Allister Frwy/Johnson City and merge onto US-281 N. In 6.5 miles, take the exit toward Jones-Maltsberger Rd/Isom Rd. Turn right onto Reunion Pl.